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KMID : 0903520040470020274
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2004 Volume.47 No. 2 p.274 ~ p.278
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Isolation of Anthraquinone Derivatives from the Root of Rumex japonicus H.
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Hwang Seon-Woo
Ha Tae-Joung
Lee Jong-Rok
Lee Jun
Nam Sang-Hae
Park Ki-Hoon
Yang Min-Suk
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Abstract
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Four anthraquinone derivatives were isolated from the root of Rumex japonicus Houtt. These compounds were identified as physcion, emodin, chrysophanol-10,10’-bianthrone and physcion-10,10’-bianthrone(a), respectively. The last compound (a), especially, showed strong activity against A549, PC-3, UO-31 and HCT-15 human cancer cell lines with IC50 values, ranging from 0.45 to 1.33 μg/ml?1.
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KEYWORD
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anthraquinone, bianthrone, emodin, physcion, cytotoxicity, Rumex japonicus HOUTT
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